Commitment of Immature CD 4 1 8 1 Thymocytes to the CD 4 Lineage Requires CD 3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor ( TCR ) Chains
نویسندگان
چکیده
From the * Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892; the ‡ Howard Hughes Medical Institute and Department of Genetics and Pediatrics, The Children’s Hospital, and the Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115; and the § Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
منابع مشابه
Commitment of Immature CD4+8+ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
As a consequence of positive selection in the thymus, immature CD4(+)8(+) double-positive, [DP] thymocytes selectively terminate synthesis of one coreceptor molecule and, as a result, differentiate into either CD4(+) or CD8(+) T cells. The decision by individual DP thymocytes to terminate synthesis of one or the other coreceptor molecule is referred to as lineage commitment. Previously, we repo...
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